WebOur lead product candidate, Trans sodium crocetinate (TSC), is being developed to enhance the diffusion of oxygen to tissues with low oxygen levels, also known as … WebAug 29, 2006 · trans-Sodium crocetinate (TSC) increases the diffusion coefficient of glucose through water by about 25−30%. This is the same percentage increase that TSC causes in the diffusivity of oxygen through water. TSC is also found to induce order in the surrounding water structure through increased hydrogen bonding of the water molecules, …

Evaluation of Trans-Sodium Crocetinate (TSC) on Peripheral

WebOct 25, 2024 · Lead drug candidate Trans sodium crocetinate (TSC) enhances the oxygen diffusion process, supporting normal, physiologic levels of oxygen diffusion at uptake and … WebNov 2, 2011 · This was an open-label, sequential-cohort, dose-escalation study in two phases. Phase 1 was a safety run-in evaluating Trans Sodium Crocetinate (TSC) in 3 subjects who received 3 doses per week for 3 weeks (9 doses in total). Phase 2 engaged 56 subjects who received 3 doses per week for 6 weeks (18 doses in total). dr. george fareed early treatment protocol

trans-Sodium Crocetinate and Diffusion Enhancement

WebTrans sodium crocetinate (TSC), a synthetic drug containing the carotenoid structure of trans crocetin has been extensively investigated in animal disease models and in human clinical trials. [2] [5] [6] Clinical trials of TSC have focused on testing the compound's effectiveness in sensitizing hypoxic cancer cells to radiation therapy in ... WebMay 16, 2016 · OBJECTIVE A new drug, trans sodium crocetinate (TSC), has been developed to enhance the delivery of oxygen to hypoxic tissues. Cancerous tumors, such as glioblastoma multiforme (GBM), are very hypoxic, and it has been suggested that radiation therapy (RT) is more beneficial if tumors are better oxyg … WebOct 2, 2014 · Trans-sodium crocetinate (TSC) is a novel carotenoid compound capable of enhancing the diffusion of small molecules in aqueous solutions. TSC improves the diffusion of oxygen and glucose, and increases oxygenation in ischemic brain tissue. TSC also dampens the intensity of an ischemic challenge during an ongoing ischemic event. dr george fechter fort washington md