WebMar 10, 2024 · Renal interstitial fibrosis, an important pathological feature of kidney aging and chronic renal failure, is regulated by mesenchymal stem cells (MSCs). ... our study confirms for the first time that CTGF is a target of miR-133b and is involved in amelioration of renal fibrosis. CTGF not only potentiates TGF-β signaling by directly binding to ... WebApr 11, 2024 · Nevertheless, clinical observations have shown that CTGF expression in the sera and fibrotic liver tissues of CHB patients is upregulated. A strong correlation between CTGF with liver fibrosis has also been reported . HBX can induce CTGF expression and secretion in hepatocytes to stimulate HSC activation . Multiple regulatory mechanisms ...
Connective-Tissue Growth Factor (CTGF/CCN2) Contributes to …
Webaffect the expression of pro-fibrotic growth factor CTGF, which is known to promote collagen and fibronectin synthesis [21]. The results showed that TGF-β1-induced CTGF … WebAug 6, 2024 · CTGF expression in fibrosis is also reported to occur in the kidney area. Exposure of mesangial cell to recombinant human CTGF significantly increased production of fibronectin and collagen type I. Induction of CTGF in rat mesangial cells due to high glucose levels is mediated by TGF-β [ 12 ]. poptropica skullduggery island walkthrough
Insights into the impact of hepatitis B virus on hepatic stellate cell ...
WebFeb 25, 2024 · FG-3019 (pamrevlumab) is a human monoclonal antibody (mAb) against CTGF that has shown efficacy in a randomized, placebo-controlled phase 2 clinical trial in subjects with idiopathic pulmonary fibrosis , as well as in phase 2 clinical trials for treatment of pancreatic cancer and Duchenne muscular dystrophy (NCT02210559 and … WebLike TGF-β, CTGF expression is increased in IPF patients. 104 Overexpression of CTGF can promote pulmonary fibrosis in animal models, 105 and blockade of CTGF signaling … WebJul 4, 2024 · Connective-tissue growth factor (CTGF) is known to exacerbate pulmonary fibrosis in radiation-induced lung fibrosis, and in this study, we show the upregulation of CTGF from a rat lung fibrosis ... poptropica space island walkthrough