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WebIt has been reported that DJ-1 can regulate Sod1 expression through the ERK1/2-ELK1 pathways, and that there is an upregulation of DJ-1 protein levels in mutant Sod1 transgenic mice. 20,21 DJ-1 forms complexes with mutant Sod1 molecules and reduces the toxicity of the latter to tissues. 21 This suggests that a compensatory mechanism may reduce the … Web006577 B6.Cg- Park7 tm1Shn /J Homozygous knock-out mice of this strain exhibit hypokinesia and nigrostriatal dopaminergic deficits. These mutant mice may be useful in studies of Parkinson's disease, dopaminergic physiology, nigrostriatal function, locomotor inactivity, and other neurobiological research. WebFeb 14, 2024 · DJ-1 KO mice have reduced adiposity, increased energy expenditure and insulin sensitivity. No developmental abnormalities were observed in DJ-1 KO mice compared with wild-type (WT) mice. hcg 10000 iu buy online