WebFeb 11, 2024 · Alzheimer’s disease (AD) is a debilitating neurodegenerative disease that causes a progressive decline in memory, language and problem solving. For decades … WebMay 21, 2024 · A list of putative mechanisms that may contribute to ketamine’s antidepressant effect follows: • Direct effects on the NMDA glutamate ionotropic receptor. • Effects on the AMPA glutamate ionotropic receptor. • Secondary glutamate synaptic release from interneurons in diverse circuits. • Secondary effects on GABA interneurons.
Non-linear variations in glutamate dynamics during a cognitive …
WebExcessive glutamate release has been linked to stress and many neurodegenerative diseases. Evidence indicates abnormalities of glutamatergic neurotransmission or glutamatergic dysfunction as playing an important role in the development of many major psychiatric disorders (e.g., schizophrenia, bipolar disorder, and major depressive … WebAug 1, 2009 · The glutamate homeostasis hypothesis of addiction. Nat Rev Neurosci 10: 561-572 ... The hierarchy of corticostriatal information processing that normally permits the prefrontal cortex to regulate ... pitchblack resources
(PDF) Kalivas PW. The glutamate homeostasis hypothesis of addiction ...
WebApr 24, 2024 · Excitotoxicity is a phenomenon that describes the toxic actions of excitatory neurotransmitters, primarily glutamate, where the exacerbated or prolonged activation of glutamate receptors starts a cascade of neurotoxicity that ultimately leads to the loss of neuronal function and cell death. In this process, the shift between normal physiological … WebThe hierarchy of corticostriatal information processing that normally permits the prefrontal cortex to regulate reinforcement-seeking behaviours is impaired by chronic drug use. A failure of the prefrontal cortex to control drug-seeking behaviours can be linked to an enduring imbalance between synaptic and non-synaptic glutamate, termed ... WebJan 10, 2024 · However, as with glutamate, glutamine takes part in multiple cell process, which complicates interpretation158. There have been over fifty 1 H‐MRS studies of the glutamate system in schizophrenia. A synthesis of their findings is complicated by methodological differences, notably in the imaging sequences used, the brain regions … pitch black resource pack