WebbPioneer factors can also actively affect transcription by directly opening up condensed chromatin in an ATP-independent process. This is a common trait of fork head box factors (which contain a winged helix DNA-binding domain that mimics the DNA-binding domain of the linker H1 histone), and NF-Y (whose NF-YB and NF-YC subunits contain … Webb1 okt. 2010 · In human, the histone-fold domain is important for centromere targeting ( Sullivanet al. 1994 ). The functionally important region within the histone-fold domain was further defined by inserting loop 1 and the α-2 helix from CENH3/CENP-A (termed the CENP-A targeting domain, or CATD) into conventional H3 ( Blacket al. 2004 ).

On the origin of the histone fold - BMC Structural Biology

Webb1 nov. 2012 · Additionally, based on the recent crystal structure of the Son of Sevenless protein, an interpretation of the sequence analysis of the histone fold domain is … Webb12 nov. 1996 · Histones H3 and H4 are highly conserved through eukaryotic evolution (1, 2), implying essential structural and functional roles.These histones exist in a precise … embc disaster recovery guide

National Center for Biotechnology Information

WebbUnlike conventional histones, CENH3 is rapidly evolving. The N-terminal tail of CENH3 barely alignable even among closely related species whereas the histone fold domain is relatively well conserved (Malik … Webb28 mars 2007 · The C-domain then evolved into the histone fold by 3D domain swapping. This scenario extends a previous hypothesis on the origin of eukaryotic core … Webb1 juni 2014 · Use of the generic term “histone fold” for core histones detracts from the true histone nature of H1 histones that, albeit with a different function, are equally important structural and functional chromosomal protein partners of the chromatin fiber. embcc patient services contact number