Irf4 protac
WebOct 15, 2015 · PROTACs provide a potency advantage of traditional small molecule inhibitors. The Arvinas PROTAC technology relies on bi-functional molecules as shown in Figure 2. In this example, a BRD4 inhibitor is connected to a thalidomide analogue via a chemical linker. The bi-functional nature of this molecule allows ligation of the E3 ligase … WebMay 13, 2024 · Proteolysis-targeting chimera (PROTAC) has been developed to be a useful technology for targeted protein degradation. A bifunctional PROTAC molecule consists of a ligand (mostly small-molecule inhibitor) of the protein of interest (POI) and a covalently linked ligand of an E3 ubiquitin ligase (E3). Upon binding to the POI, the PROTAC can …
Irf4 protac
Did you know?
WebSmall molecules 10-E-09, 12-P-16 and 13-I-18 decreased IRF4 protein levels in myeloma cells and decreased viable cell levels of a variety of myeloma cells compared to IRF4 negative cells . As mentioned previously, many cancer types were dependent on specific transcription factors nominated by the dependency map project . Indeed ... WebNov 14, 2024 · IRF4 expression is shown on the x-axis using a declining expression gradient. Close modal. Discussion. Here we report a novel B cell–specific role of IRF4 in regulating the CLL/T-cell cross talk and demonstrate that lack of IRF4 in murine CLL contributes to enhanced CLL tumor immune evasion and a more aggressive type of disease with short ...
WebSep 15, 2015 · Finally, MICA expression was enhanced in IRF4-silenced cells, indicating a specific suppressive role of this transcription factor on MICA gene expression in MM cells.Taken together, these findings describe novel molecular pathways involved in the regulation of MICA and PVR/CD155 gene expression and identify the transcription factors …
WebApr 4, 2024 · The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member … WebNov 5, 2024 · IRF4 was identified to be enriched in regions of accessible chromatin upon BCL7A loss. IRF4 is an oncoprotein transcription factor and is a direct target of myc, generating a feedback loop in MM cells. IRF4 dependency is central to myeloma cell proliferation. Most importantly, we found that in addition to functions within the m …
WebMar 2, 2024 · CRISPR knockout of IRF4 attenuated c-Myc levels and increased sensitivity to a BET protein inhibitor. Co-treatment with BET inhibitor or BET-PROTAC and ibrutinib or …
Web• BCL6 PROTAC® degraders demonstrate potent, on mechanism degradation of BCL6 and growth inhibition of numerous DLBCL cell lines • Orally administered ARVN-71228 shows … ikea wall shelves screwsWebThalidomide and the immunomodulatory drug, lenalidomide, are therapeutically active in hematological malignancies. The ubiquitously expressed E3 ligase protein cereblon (CRBN) has been identified as the primary teratogenic target of thalidomide. Our studies demonstrate that thalidomide, lenalidomide … is there tax on gift cards in canadaWebFeb 23, 2024 · Although all five patients received lenalidomide and dexamethasone during their treatment, we did not detect changes in proteins involved in the mechanism of IMiDs (CRBN, DDB1, IKZF1, IKZF3,... is there tax on gasWebJun 8, 2024 · The design of proteolysis-targeting chimeras (PROTACs) is a powerful small-molecule approach for inducing protein degradation. PROTACs conjugate a target … is there tax on garbage bagsWebIn heart failure, iron deficiency is a common comorbid disease that negatively influences exercise tolerance, number of hospitalizations and mortality rate, and this is why iron iv … ikea wall shelves for shoesWebChIP of MYC binding to the IRF4 first intron in human blood B cells, either unstimulated or activated with PMA and ionomycin for 6 h. ctrl, control. g, MYC and IRF4 are more highly expressed in ... ikea wall shelves near meWebTherapeutic Protein Degradation - Baran Lab is there tax on gift cards in ny