WitrynaIn recent years, para-quinone methides (p-QMs) have emerged as attractive and versatile synthons in organic synthesis owing to their high reactivity.Consequently, p-QM … WitrynaHerein, we describe a novel transition metal-free, umpolung strategy for the α-arylation of ketones by capturing transient oxyallyl cations with arylboronic acids. A variety of α …

Recent advances in the asymmetric transformations of achiral ...

WitrynaWe described a Rh(III)-catalyzed and solvent-controlled C–H bond functionalization of 2-(1H-pyrazol-1-yl)pyridine with internal alkynes, which provided a straightforward way for the divergent synthesis of either C–H alkenylation products or indazole products in moderate to good yields.Control experiments were conducted, and a mechanism … WitrynaTalaronoids A–D (1–4), four diterpenoids with an unexpected tricyclic 5/8/6 carbon skeleton isolated from Talaromyces stipitatus, represent a new class of fusicoccane diterpenoids and the first examples of natural products with a benzo[a]cyclopenta[d]cyclooctane skeleton.Their structures were established by a … cutesy cry of shock nyt

Transition-metal-free direct C-3 cyanation of quinoxalin-2 (1

WitrynaA practical synthesis of immucillins BCX-1777 and BCX-4430 is disclosed. Highlights of the synthesis include the addition of lithiated 9-deazapurine derivative 10 to the stable tri-O-benzyl cyclic nitrone 13 to form the imino-C-nucleoside skeleton, and an efficient copper-catalysed Ullmann-type amination to install the amino group on the … Witrynaa Department of Medicinal Chemistry and Pharmaceutical Analysis, School of Pharmacy, Fourth Military Medical University, 169 Changle West Road, Xi'an, PR … WitrynaOrganic Chemistry Frontiers Visible-light mediated oxidative ring expansion of anellated cyclopropanes to fused endoperoxides with antimalarial activity † Simon Budde,a … cheap burgundy wine brands