WebFeb 12, 2024 · Question 15 from the second paper of 2014 explored the terms "tachyphylaxis" and "tolerance", which is broadly related to the regulation of receptor number and activity. Because the rest of the discussion of tolerance and tachyphylaxis belongs to the syllabus section on variability in drug response , these matters will only be discussed … WebThe problem of tachyphylaxis can occur with prolonged use of the drug because of depletion of noradrenaline (Moss and Renz, 2000). Ephedrine also exhibits mild direct β-adrenoceptor activity ( Kobayashi et al ., 2003 ) with increases in cardiac output of up to 20% due to increases in heart rate and stroke volume ( Cohn, 1965 ).
Tachyphylaxis - an overview ScienceDirect Topics
WebFeb 6, 2024 · Tachyphylaxis is defined as a rapid decrease in response to repeated doses over a short time period. Notably, the authors firmly establish that speed is of the essence … WebDefinition Tachyphylaxis is the continued or repeated exposure to a drug that may lead to a weakened pharmacological response. This presumed to be a consequence of diminished receptor sensitivity in response to consistent stimulation by a drug agonist, which produces a diminished pharmacological response in consequence. cdhb learning
Leptin: What It Is, Function & Levels - Cleveland Clinic
WebTachyphylaxis and the development of drug tolerance have both long been described as phenomena causing reduced drug efficacy. But is there a difference between the two? Tachyphylaxis can develop quite quickly when drugs are used repeatedly over a short period, with no response occurring when the dosage is increased. WebTachyphylaxis can best be described as: A) an unexpected increase in heart rate as a side effect of a drug. B) an allergic reaction that occurs when a drug is administered for the … WebCardiac dysrhythmias of various types (including occasional ventricular dysrhythmias) when dobutamine is used as a stress-inducing agent during echocardiography have been described [8].A 56-year-old woman with dilated cardiomyopathy developed QT interval prolongation and torsade de pointes during infusion of dobutamine in a low dose (2.5 … cdhb medicines information