The cystine/glutamate antiporter
WebThe x c − cystine/glutamate antiporter is a plasma membrane transporter mediating cellular uptake of cystine in exchange for intracellular glutamate with a stoichiometry of 1 : 1 (Lo … WebAug 15, 2024 · Conversely, blocking the activity of cystine/glutamate antiporter (System X C−) is effective in inhibiting cystine uptake, which will induce a deficiency of antioxidant defenses of cells and trigger ferroptosis, a recently described iron-dependent and lipid peroxidation-driven non-apoptotic cell death [ [14], [15], [16] ].
The cystine/glutamate antiporter
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WebJun 13, 2005 · Cystine:glutamate antiporter activity Specific Function ... Uniprot Name Cystine/glutamate transporter Molecular Weight 55422.44 Da. References. Tomi M, Hosoya K, Takanaga H, Ohtsuki S, Terasaki T: Induction of xCT gene expression and L-cystine transport activity by diethyl maleate at the inner blood-retinal barrier. Invest Ophthalmol … WebJan 7, 2008 · The x cystine/glutamate antiporter is a major plasma membrane transporter for the cellular uptake of cystine in exchange for intracellular glutamate. Its main …
WebxCT, also called SLC7A11, is the light chain component of the cysteine/glutamate amino acid exchange transporter system Xc (1,2). System Xc is composed of two subunits, the light chain (xCT) and the … WebFeb 2, 2013 · The antiporter system x c − imports the amino acid cystine, the oxidized form of cysteine, into cells with a 1:1 counter-transport of glutamate. It is composed of a light …
WebLewerenz, J., Hewett, S. J., Huang, Y., Lambros, M., Gout, P. W., Kalivas, P. W., … Maher, P. (2013). The Cystine/Glutamate Antiporter System xc− in Health and ...
WebThe antiporter system x c– is a sodium independent amino acid transporter that imports extracellular cystine in exchange for exporting intracellular glutamate 1. Given the key …
WebFeb 2, 2024 · In the present study, we found that autophagy has a selective role in sustaining cysteine (Cys) pools in PDAC. One of the major mechanisms of Cys homeostasis is through the import of cystine (the oxidized dimer of cysteine) through system x c −, a cystine/glutamate antiporter composed of SLC7A11 (xCT) and SLC3A2 . first aid kits for business officesWebOct 1, 2024 · The cystine/glutamate antiporter SLC7A11 (also commonly known as xCT) functions to import cystine for glutathione biosynthesis and antioxidant defense and is overexpressed in multiple human cancers. european federation of art therapyWebApr 24, 2024 · The cystine–glutamate antiporter xCT is frequently overexpressed in cancer and fuels the production of the antioxidant glutathione; thus, tumors prone to redox stress … european federation of origin winesWebOct 1, 2024 · The cystine/glutamate antiporter SLC7A11 (also commonly known as xCT) functions to import cystine for glutathione biosynthesis and antioxidant defense and is overexpressed in multiple human cancers. Recent studies revealed that SLC7A11 overexpression promotes tumor growth partly through suppressing ferroptosis, a form of … european federation of internal medicineWebAbstract System x (c) (-) is an amino acid antiporter that typically mediates the exchange of extracellular l-cystine and intracellular L-glutamate across the cellular plasma membrane. … european fellowship gastroenterologyWebApr 12, 2024 · The sodium-independent cystine-glutamate antiporter plays an important role in extracellular cystine uptake. It comprises the transmembrane protein, xCT and its chaperone, CD98. first aid kits for backpackingCystine/glutamate transporter is an antiporter that in humans is encoded by the SLC7A11 gene. The SLC7A11 gene codes for a sodium-independent cystine-glutamate antiporter that is chloride dependent, known as system Xc- or xCT. It regulates synaptic activity by stimulating extrasynaptic receptors … See more SLC7A11 is a member of a heterodimeric Na+-independent anionic amino acid transport system highly specific for cystine and glutamate. This antiporter imports cystine and exports glutamate, which are both … See more Many central nervous system (CNS) disorders are due to a dysfunction in glutamate signaling. Glutamate is transported via … See more There are many mechanisms that exist to regulate the expression of system Xc-, although it is not the sole determinate of extracellular … See more • Bridges CC, Kekuda R, Wang H, Prasad PD, Mehta P, Huang W, Smith SB, Ganapathy V (January 2001). "Structure, function, and regulation of human cystine/glutamate transporter in retinal pigment epithelial cells". Investigative Ophthalmology & … See more european festivals in september